Gender predisposition to myopia shifts to girls in the young generation. | IOVS (2024)

Gender predisposition to myopia shifts to girls in the young generation. | IOVS (1)

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June 2021

Volume 62, Issue 8

  • Issue

Open Access

ARVO Annual Meeting Abstract| June 2021

Gender predisposition to myopia shifts to girls in the young generation.

Clair Enthoven; Annechien E.G. Haarman; Joanna Swierkowska; Willem Tideman; Jan Roelof Polling; Virginie JM Verhoeven; Caroline C. W. Klaver

Author Affiliations & Notes

  • Clair Enthoven

    Ophthalmology & Epidemiology, Erasmus MC, Rotterdam, Zuid-Holland, Netherlands

  • Annechien E.G. Haarman

    Ophthalmology & Epidemiology, Erasmus MC, Rotterdam, Zuid-Holland, Netherlands

  • Joanna Swierkowska

    Ophthalmology & Epidemiology, Erasmus MC, Rotterdam, Zuid-Holland, Netherlands
    Instytut Genetyki Czlowieka Polskiej Akademii Nauk, Poznan, Poland

  • Willem Tideman

    Ophthalmology & Epidemiology, Erasmus MC, Rotterdam, Zuid-Holland, Netherlands

  • Jan Roelof Polling

    Ophthalmology & Epidemiology, Erasmus MC, Rotterdam, Zuid-Holland, Netherlands
    Orthoptics & Optometry, Hogeschool Utrecht, Utrecht, Utrecht, Netherlands

  • Virginie JM Verhoeven

    Ophthalmology & Epidemiology, Erasmus MC, Rotterdam, Zuid-Holland, Netherlands
    Clinical Genetics, Erasmus MC, Rotterdam, Zuid-Holland, Netherlands

  • Caroline C. W. Klaver

    Ophthalmology & Epidemiology, Erasmus MC, Rotterdam, Zuid-Holland, Netherlands
    Ophthalmology, Radboudumc, Nijmegen, Gelderland, Netherlands

  • Footnotes

    Commercial Relationships Clair Enthoven, None; Annechien E.G. Haarman, None; Joanna Swierkowska, None; Willem Tideman, None; Jan Roelof Polling, None; Virginie Verhoeven, None; Caroline Klaver, None

  • Footnotes

    Support Oogfonds; EMBO Short-term Fellowship (8529)

Investigative Ophthalmology & Visual Science June 2021, Vol.62, 2331. doi:

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      Clair Enthoven, Annechien E.G. Haarman, Joanna Swierkowska, Willem Tideman, Jan Roelof Polling, Virginie JM Verhoeven, Caroline C. W. Klaver; Gender predisposition to myopia shifts to girls in the young generation.. Invest. Ophthalmol. Vis. Sci. 2021;62(8):2331.

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Abstract

Purpose : Previous studies have suggested that female gender is a risk factor for myopia. The underlying mechanism is not well understood, and gender-specific factors such as age of growth spurt have been proposed. The aim of this study was to explore gender differences in myopia development in two prospective population-based cohorts from different generations, and to find possible explanations.

Methods : Analyses were performed in the birth cohort study Generation R (n=7229) and in the elderly Rotterdam Study I-III (45+ yrs; n=8674). Cycloplegic refraction was measured in the children at 6, 9, and 13 years, automated refraction was measured in the adults, and axial length and height was measured in both. Myopia was defined as spherical equivalent ≤-0.5D in at least one eye. Lifestyle factors including near work and outdoor exposure were assessed in the children and level of education in the adults, both by questionnaire. The association between gender and myopia was tested using Cox proportional hazards and logistic regression models adjusted for age; change in height, lifestyle factors and education were investigated as possible mediators.

Results : Myopia prevalence increased from 2.5%, to 11.5% and 22.5% at age 6, 9, and 13 years in the children, respectively; the prevalence was 30.6% in the adults. Female gender was associated with myopia in the children (HR=1.14 95% CI=1.02-1.27), but was inversely associated in the adults (OR=0.88 95%CI=0.80-0.96). Mediators of the association in children were outdoor exposure, growth in height, sport participation, reading time, and number of books read per month; these mediators together attenuated the effect of gender with 34.9% and reduced risk to HR=1.09 (95%CI=0.97-1.23). Education was the most important mediator of the association in adults, attenuating the effect with 89.7% to OR=0.98 (95%CI=0.90-1.09).

Conclusions : In our study, myopia was more common in girls in the young generation, but more common in men in the older generation. This paradigm shift and our mediation analysis provide compelling evidence that lifestyle factors and education are strong drivers of myopia. In the generations to come, particularly girls should be guided to adhere to protective behaviour.

This is a 2021 ARVO Annual Meeting abstract.

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    Gender predisposition to myopia shifts to girls in the young generation. | IOVS (2024)

    FAQs

    Gender predisposition to myopia shifts to girls in the young generation. | IOVS? ›

    The results show that men had a higher prevalence of myopia in our study of older generations; while girls had a higher prevalence in the young generation. Our hypothetical interventions suggest that these generation-specific gender preponderances were largely due to education

    education
    Teaching is the practice implemented by a teacher aimed at transmitting skills (knowledge, know-how, and interpersonal skills) to a learner, a student, or any other audience in the context of an educational institution. Teaching is closely related to learning, the student's activity of appropriating this knowledge.
    https://en.wikipedia.org › wiki › Teaching
    and, possibly, lifestyle factors in youth.

    Why is myopia more common in females? ›

    [7,8] Many factors are responsible for the higher myopia rate of girls than that of boys, including earlier growth conditions, more limited outdoor activity time than boys. However, certain internal factors, like hormone endocrine, are yet to be investigated. Xie et al.

    What is gender myopia? ›

    Results: It was found that myopia occurs more frequently in girls (7.4%) than in boys (5.1%) - p < 0.001. Hyperopia occurs more frequently in boys (19.6%) than in girls (18.2%) - p < 0.001.

    What are some of the reasons for the increased prevalence of myopia in the younger generation? ›

    Experts link this increase of persons with myopia to the increase in daily hours focused on the use of electronic devices with a screen that also increases sedentary lifestyle. It is estimated that young people use the mobile phone for 4 to 8 hours a day and the computer for 2 to 4 hours a day.

    Is there a genetic predisposition to myopia? ›

    In a large number of studies, children with myopic parents have been shown to be more likely myopic compared with those with non-myopic parents. Having two myopic parents generally poses a greater risk than having only one. These correlations are well established in populations of both East Asian and Caucasian origin.

    Why is myopia more common in children? ›

    Causes Of Myopia In Children

    One theory to explain the sharp increase in nearsightedness in kids in recent decades has to do with screen time. “Thirty years ago, kids didn't spend time with technology like phones, laptops and tablets that required them to look at screens close up for hours a day,” says Dr. Le.

    What age group is myopia most common? ›

    Myopia, or nearsightedness, is a common vision problem that often begins between the ages of 6 and 14. It affects an estimated 5% of preschoolers, about 9% of school aged children and 30% of adolescents. Children are more likely to develop myopia if their parents are nearsighted.

    What are the two main causes of myopia? ›

    This problem happens when the shape or condition of the cornea — or the shape of the eye itself — causes an inaccurate focusing of the light passing into the eye. Nearsightedness usually results when the eye is too long or oval-shaped rather than round. It also may result when the curve of the cornea is too steep.

    Does myopia become more common as we age? ›

    Many people will not experience an increasing degree of myopia as they exit their 20s, but diagnosis as a child will usually remain with someone their whole life. It's rare for myopia to continue to get worse as you age past your early 20s.

    What is the main cause of the rapidly rising rates of myopia? ›

    The World Health Organization estimates that half the world's population may be myopic by 2050. Given that genes don't change that quickly, environmental factors, especially children's decreased exposure to outdoor light, are the likely cause of this rise in myopia, experts believe.

    What is the biological cause of myopia? ›

    If you have myopia, more than likely, at least one or both of your biological parents do, too. Eye experts are still unsure of the exact cause of myopia, but believe it to be a mix of hereditary and environmental factors. It's possible that you can inherit the ability to be myopic.

    Is myopia inherited from mother or father? ›

    Nearsightedness (Myopia).

    If you read our Mother's Day post, you know that nearsightedness can be inherited from your mom but is even more likely to be inherited from your dad. While nearsightedness is a result of both genetic and environmental factors, eye shape is inherited.

    Who is most affected by myopia? ›

    Myopia is the most common ocular disorder worldwide, it is the leading cause of visual impairment in children, and its incidence is increasing rapidly.

    Is myopia recessive or dominant? ›

    Nearsightedness is usually neither a dominant nor recessive trait. In most cases, it occurs due to a mixture of genetic and environmental factors, rather than just one gene. The exception to this is when a person inherits a specific genetic condition that causes myopia as a symptom.

    Is myopia more common in males? ›

    First, some of the participants (3–4%) received physical examinations before or after the age of 19 (age range: 18–35 years). This may have led to some variation in the results. Second, we only included men in this study. Myopia has been reported to be more prevalent in women than in men45.

    Who is at higher risk of developing myopia? ›

    More near based activities

    Age: Children who were exposed to near work at a younger age (6 years or less) were more likely to develop myopia.

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