The Substance: release date, trailer, cast, plot, reviews and everything we know about the Demi Moore movie (2025)

The Substance: release date, trailer, cast, plot, reviews and everything we know about the Demi Moore movie (1)

There's always a breakout movie at the Cannes Film Festival, and one of the early contenders for that title is the 2024 new movie, The Substance from Coraline Fargeat and starring the popular 90s actress Demi Moore, in what could be something of a comeback role on the big screen.

The Substance is the latest entry in the body-horror genre, which has seen some cult favorite movies from the likes of David Cronenberg (Crimes of the Future, The Fly), Julia Ducournau (Titane, Raw) and John Carpenter (The Thing, Prince of Darkness), among others. With early buzz describing The Substance as "spectacular and revolting" and "a diabolically delightful B movie that brings laughs, thrills and blood… lots and lots of blood," we may have another strong entry to the genre on our hands.

Interested? Here is everything you need to know about The Substance.

The Substance release date

After premiering at the 2024 Cannes Film Festival, The Substance is coming to movie theaters in the US, UK and other locations on September 20 (early screenings starting September 19).

The movie is getting one more special screening, as the Toronto International Film Festival has announced it'll be part of its Midnight Madness block of programming.

The Substance cast

The main stars of The Substance are Demi Moore as Elizabeth Sparkle, Margaret Qualley as Sue and Dennis Quaid as Harvey.

As we said, Moore was at the peak of her stardom in the 1990s, starring in the likes of Ghost, A Few Good Men and Indecent Proposal. While she has continued working pretty steadily since then, she hasn't led as many high-profile projects in a while, which is what makes The Substance an exciting prospect for her as the movie generates buzz. In addition to the movie, 2024 has also seen her star in the limited series Feud: Capote vs the Swans.

On the flip side, Qualley has been a rising star in recent years, starring in The Leftovers, Once Upon a Time in Hollywood, Maid and, most recently, Drive-Away Dolls. The Substance is actually the second movie she had premiere at the 2024 Cannes Film Festival, the other being Yorgos Lanthimos' Kinds of Kindness.

Quaid is a long-time Hollywood veteran, known for things like The Right Stuff, The Rookie, Far From Heaven and The Parent Trap. Like his co-stars, he's been busy recently, as since 2023 he has appeared in On a Wing and a Prayer, Full Circle, Strays, The Hill, The Long Game and Lawmen: Bass Reeves.

Other members of The Substance cast include Hugo Diego Garcia, Joseph Balderrama, Oscar Lesage, Gore Abrams and Matthew Géczy.

The Substance: release date, trailer, cast, plot, reviews and everything we know about the Demi Moore movie (2)

The Substance plot

An original script by Fargeat, here is the synopsis for The Substance, a little different than your typical synopsis:

“Have you ever dreamt of a better version of yourself?
You. Only better in every way.
Seriously.
You've got to try this new product. It's called The Substance.
IT CHANGED MY LIFE.

“It generates another you.
A new, younger, more beautiful, more perfect, you.
And there's only one rule: You share time.
One week for you. One week for the new you.
Seven days each. A perfect balance.
Easy. Right?
If you respect the balance… what could possibly go wrong?"

The Substance trailer

The official trailers for The Substance are now online. Watch it directly below:

THE SUBSTANCE | Official Trailer | In Theaters September 20 - YouTubeThe Substance: release date, trailer, cast, plot, reviews and everything we know about the Demi Moore movie (3)

Watch On

THE SUBSTANCE | Official Teaser | Coming Soon - YouTubeThe Substance: release date, trailer, cast, plot, reviews and everything we know about the Demi Moore movie (4)

Watch On

Also check out an official clip from the movie right here:

THE SUBSTANCE | Official Clip | Coming Soon - YouTubeThe Substance: release date, trailer, cast, plot, reviews and everything we know about the Demi Moore movie (5)

Watch On

The Substance reviews

Read WTW's The Substance review to find out why we think it is one of the best movies of the year (thought definitely something you need to know what you're getting into).

We're not the only ones who've enjoyed the movie. As of September 16, The Substance is "Certified Fresh" on Rotten Tomatoes with a score of 89%.

Coralie Fargeat movies

The Substance is Fargeat's second feature-length movie, following her 2017 movie Revenge, which also received strong reviews. Her other major credit so far in her career is directing an episode of Netflix's The Sandman.

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The Substance: release date, trailer, cast, plot, reviews and everything we know about the Demi Moore movie (6)

Michael Balderston

Michael Balderston is a DC-based entertainment and assistant managing editor for What to Watch, who has previously written about the TV and movies with TV Technology, Awards Circuit and regional publications. Spending most of his time watching new movies at the theater or classics on TCM, some of Michael's favorite movies include Casablanca, Moulin Rouge!, Silence of the Lambs, Children of Men, One Flew Over the Cuckoos Nest and Star Wars. On the TV side he enjoys Only Murders in the Building, Yellowstone, The Boys, Game of Thrones and is always up for a Seinfeld rerun. Follow on Letterboxd.

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